Monday, September 27, 2010
Session 6.1 Instructional Course (pre-registration required)
How to set up Clinical Studies
07:30 AM - 08:15 AM
Room: Llevant 3,4 & 5
Instructor: Kai Mithoefer (US)
Session 6.2 Instructional Course (pre-registration required)
How to interprete histological pictures
07:30 AM - 08:15 AM
Room: Tramuntana 2 & 3
Instructor: Robert Whiteside (CA)
Session 6.3 Workshop
Meet the Experts (Basic Science)
07:30 AM - 08:15 AM
Room: Garbi
Moderators: Bruce Caterson (UK), Sally Roberts (UK)
Session 7.0 Plenary
Stem Cells for Cartilage Repair
08:30 AM - 09:30 AM
Room: Auditorium
Moderators: Anthony Hollander (UK), James Hui (SG)
7.1 Regulatory limitations for the use of stem cells
J.H.P. Hui, Singapore/SG
7.2 Human cultured chondrocytes and tissue stem cells for tissue engineering of permanent cartilage
K. Hoshi, Tokyo/JP
7.3 Principles of recruitment and handling of stem cells (PRP/Blood/MSC)
W. Richter, Heidelberg/DE
Session 8.1
Joint Instability
09:30 AM - 10:30 AM
Room: Auditorium
Moderators: Kai Mithoefer (US), Nick Sgaglione (US)
8.1.1 How much joint instability can healthy cartilage compensate for?
J.M. Scopp, Salisbury/US
8.1.2 The posterolateral corner of the knee
T. Spalding, J. Bird, Coventry/UK
8.1.3 Instability & Cartilage defects in the Ankle
M. Wiewiorski, Basel/CH
Session 8.2
Biomarkers
09:30 AM - 10:30 AM
Room: Tramuntana 2 & 3
Moderators: Bruce Caterson (UK), Stefan Lohmander (SE)
8.2.1 Emerging biomarker technology
D.R. Eyre, Seattle, WA/US
8.2.2 Using Biomarkers to Monitor Joint Tissue Pathology and Repair
V. Byers - Kraus, Durham, NC/US
8.2.3 Can biomarkers be used as outcome measures in cartilage repair?
S.L. Lohmander, Lund/SE
Session 8.3
Recent News in Regulatory Affairs
09:30 AM - 10:30 AM
Room: Garbi
Moderators: Michael Buschmann (CA), Kenneth Zaslav (US)
8.3.1 Regulatory experience with ChondroCelect in Europe
W. Dalemans, Leuven/BE
8.3.2 Regulatory Affairs in Japan
M. Shikano, Tokyo/JP
8.3.3 Recent News in Regulatory Affairs in the USA
K.R. Zaslav, Richmond/US
Coffee Break
10:30 AM - 11:00 AM
Room: Technical Exhibition
Session 9.1 Free Papers
Allografts
11:00 AM - 12:30 PM
Room: Auditorium
Moderators: Ernst Hunziker (CH), William Bugbee (US)
9.1.1 Overview and Introduction
E. Hunziker, Bern/CH
9.1.2 Predictors of Osteochondral Allograft Failure
W. Bugbee, A. DeYoung, S. Görtz, La Jolla, CA/US
9.1.3 The Optimal Temperature for the Long Term ex-Vivo Cartilage Storage: 11°C is Superior to 4°C, 23°C, and 35°C
A. Alibegovic, R. Blagus, M. Drobnič, Ljubljana/SI
9.1.4 Long-Term Survival of Concurrent Meniscus Allograft Transplantation and Articular Cartilage Repair: A Prospective 2- to 12-Year Follow-Up Evaluation
K.R. Stone, W. Adelson, J.R. Pelsis, A. Walgenbach, T. Turek, San Francisco, CA/US
9.1.5 Immunosuppressed versus non immunosuppressed bipolar fresh osteochondral allograft in the treatment of end stage ankle arthritis: a clinical and histological comparison
F. Vannini, R. Buda, M. Cavallo, A. Ruffilli, R. Ghermandi, B. Grigolo, S. Neri, S. Giannini, Bologna/IT
9.1.6 Isolated Osteochondral Allografting of the Femoral Trochlea
W. Bugbee, A. DeYoung, S. Görtz, La Jolla, CA/US
9.1.7 Particulated juvenile cartilage allograft transplantation for repair of high grade chondral lesions
J. Farr1, J. Kercher2, M. Salata2, J. Yao3, 1Indianapolis, IN/US, 2Chicago/US, 3Austin, TX/US
9.1.8 Chondral defect repair with particulated juvenile cartilage allograft
J. Farr1, J. Yao2, 1Indianapolis, IN/US, 2Austin, TX/US
9.1.9 Skeletal maturity does not affect the healing response of articular cartilage using scaffold-free tissue-engineered construct (TEC) derived from allogenic synovial mesenchymal stem cells. -A large animal study-
K. Shimomura1, W. Ando1, K. Tateishi1, R. Nansai2, H. Fujie2, D.A. Hart3, T. Kanamoto1, T. Mae1, K. Nakata1, K. Shino4, H. Yoshikawa1, N. Nakamura5, 1Suita/JP, 2Tokyo/JP, 3Calgary/CA, 4Habikino/JP, 5Osaka/JP
Session 9.2 Free Papers
Chondrocytes
11:00 AM - 12:30 PM
Room: Llevant 3,4 & 5
Moderators: Charles Archer (UK), Susan Chubinskaya (US)
9.2.1 Overview and Introduction
C. Archer, Cardiff/UK
9.2.2 Chondrocyte gene expression is affected by VSOP-labeling in long-term in vitro MRI tracking
C.B. Foldager1, M. Pedersen2, S. Ringgard2, C. Bünger1, M. Lind1, 1Aarhus C/DK, 2Aarhus N/DK
9.2.3 Modelling of tissue formation in chondrocyte filter cultures
C.J. Catt1, W. Schuurman2, B. Sengers1, C.P. Please1, W.J.A. Dhert2, J. Malda2, 1Southampton/UK, 2Utrecht/NL
9.2.4 A novel 3D tissue assembly approach for cartilage tissue engineering applications
S. Stroebel1, J. Malda2, T.B.F. Woodfield1, 1Christchurch/NZ, 2Utrecht/NL
9.2.5 Stem cell surface marker SSEA-4 levels correlate with enhanced chondrogenic potential of cultured human osteoarthritic chondrocytes
K. Schrobback1, T.B.F. Woodfield2, R. Crawford1, D.W. Hutmacher1, T. Klein1, 1Brisbane/AU, 2Christchurch/NZ
9.2.6 Polyglycan promotes the intrinsic damage-repair response of chondrocytes in equine articular cartilage explants.
A. Getgood1, L. Barr1, D. Caborn2, N. Rushton1, F.M. Henson1, 1Cambridge/UK, 2Louisville/US
9.2.7 Redifferentiation in Hyaff scaffolds affects the chondrogenic potential in vivo
C. Brantsing, H. Stenhamre, S. Concaro, M. Brittberg, A. Lindahl, Göteborg/SE
9.2.8 The tumor gene survivin is expressed in primary human chondrocytes – a novel mechanism of cartilage protection and regeneration?
P. Lechler1, S. Doukas1, T. Renkawitz1, S. Anders1, J. Grifka1, S. Balakrishnan2, R.H. Straub3, J. Schaumburger1, 1Bad Abbach/DE, 2London/UK, 3Regensburg/DE
9.2.9 Beta-1 integrins are crucial for structural organization of the articular cartilage but dispensable for chondrocyte metabolism.
A. Raducanu1, M. Stolz2, I. Drosse3, E. Hunziker4, A. Aszodi1, 1Martinsried/DE, 2Southampton/UK, 3Munchen/DE, 4Bern/CH
Session 9.3 Free Papers
Growth Factors, Morphogens & Cytokines
11:00 AM - 12:30 PM
Room: Tramuntana 2 & 3
Moderators: Constance Chu (US), Mary Goldring (US)
9.3.1 Overview and Introduction
M. Goldring, New York/US
9.3.2 Expression patterns of proinflammatory cytokines and matrix metalloproteinases before and after autologous chondrocyte transplantation (MACT) in a leporine animal model: The influence of varying in-vitro settings
M. Sauerschnig1, G.M. Salzmann2, M. Berninger1, T. Sütfels1, M. Schönfelder1, S. Vogt1, P.B. Schöttle1, A.B. Imhoff1, 1Munich/DE, 2Freiburg/DE
9.3.3 The combination of IL-4 and IL-10 protects against blood-induced cartilage damage
M.E.R. van Meegeren, N.W.D. Jansen, G. Roosendaal, F.P.J.G. Lafeber, Utrecht/NL
9.3.4 Platelet-Rich Plasma intra-articular injections versus viscosupplementation as treatment for early osteoarthritis: a comparative study
E. Kon1, B. Mandelbaum2, R. Buda1, G. Filardo1, M. Delcogliano3, A. Timoncini1, A. Di Martino1, S. Patella1, S. Giannini1, M. Marcacci1, 1Bologna/IT, 2Santa Monica, CA/US, 3Roma/IT
9.3.5 Comparing the chondroprotective capability of curcumin (Curcuma longa) and curcumin derivatives against IL-1β-mediated chondrolysis
M.J. Goldstein1, N.V. Shah1, R. Greenwald1, P. Razzano1, L. Golub2, D. Grande1, 1Manhasset, NY/US, 2Stony Brook, NY/US
9.3.6 Lack of disease modifying activity of celecoxib in osteoarthritis: a randomized clinical trial
S.C. Mastbergen1, T.N. De Boer1, A.M. Huisman2, A.A. Polak2, J.W.J. Bijlsma1, F.P.J.G. Lafeber1, 1Utrecht/NL, 2Rotterdam/NL
9.3.7 Treatment of painful bone marrow edema syndrome with intravenous bisphosphonates
C. Bartl1, G.M. Salzmann2, A.B. Imhoff3, R. Bartl4, 1Ulm/DE, 2Freiburg/DE, 3München/DE, 4Munich/DE
9.3.8 Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes
H. Sasaki, T. Matsushita, R. Kuroda, K. Takayama, K. Ishida, N. Fujita, S. Kubo, T. Matsumoto, M. Kurosaka, Kobe/JP
9.3.9 Initial Phase 1 safety of retrovirally transduced human chondrocytes expressing TGF-b1 (TG-C)
C.-W. Ha, Seoul/KR
Session 9.4 Free Papers
Biomaterials & Physical Stimuli
11:00 AM - 12:30 PM
Room: Garbi
Moderators: Caroline Hoemann (CA), Robert Sah (US)
9.4.1 Overview and Introduction
C.D. Hoemann, Montreal, QC/CA
9.4.2 Mechanically Induced in vitro Chondrogenesis under Simulation of Different Chondrocyte Implantation Techniques
N. Wang1, S. Grad1, M. Stoddart1, M. Alini1, N. Sudkamp2, G.M. Salzmann2, 1Davos/CH, 2Freiburg/DE
9.4.3 Chitosan-Glycerol Phosphate/Blood Implants Alter Maturation and Location of Chondrogenic Foci in Marrow Stimulated Cartilage Repair
A. Chevrier1, C.D. Hoemann1, J. Sun2, M.D. Buschmann1, 1Montreal/CA, 2Laval/CA
9.4.4 Presolidified chitosan-based implants for osteochondral repair in sheep
A. Bell1, M. Lowerison1, J. Sun2, V. Lascau-Coman3, M.B. Hurtig1, C.D. Hoemann3, 1Guelph, ON/CA, 2Laval, QC/CA, 3Montreal, QC/CA
9.4.5 An In Vivo Study to Clarify Mechanisms of Spontaneous Cartilage Regeneration Induced by Implantation of a Novel Double-network Gel: Determination of the Effect of the Two Component Gels on the Regeneration
M. Ogawa1, N. Kitamura2, K. Arakaki2, S. Onodera2, T. Kurokawa2, J.P. Gong2, Y. Tanaka1, Y. Takakura1, K. Yasuda2, 1Kashihara/JP, 2Sapporo/JP
9.4.6 Testing tissue time dependant mechanical properties by AFM: experimental procedures and finite element modeling of soft agarose model gels and articular cartilage
R. Gottardi1, E. Landini1, D. Carnelli2, M. Taffetani2, P. Vena2, R. Raiteri1, 1Genova/IT, 2Milano/IT
9.4.7 The application of a chondroitin sulfate-bone marrow adhesive towards meniscal repair
J.A. Simson, I. Strehin, J. Elisseeff, Baltimore/US
9.4.8 Effects of combined 3D- and hypoxic culturing on cartilage-specific gene expression in human chondrocytes
C.B. Foldager, A.B. Nielsen, S. Munir, M. Ulrich-Vinther, K. Søballe, C. Bünger, M. Lind, Aarhus/DK
9.4.9 Biomechanical Optimization of a Novel Polycarbonate-Urethane Meniscal Implant
J.J. Elsner1, E. Linder-Ganz1, G. Zur1, R. Arbel2, F. Guilak3, A. Shterling1, 1Netanya/IL, 2Tel Aviv/IL, 3Durham, NC/US
Session 10.1 Smith & Nephew Satellite Symposium
The results are in. Clinical outcomes revealed.
12:45 PM - 01:45 PM
Room: Auditorium
Moderators: Nick Sgaglione (US)
10.1.1 Treatment Options: Choosing the right solution for your patient
D.B. Saris, Utrecht/NL
10.1.2 TRUFIT CB Plug: 4-year Clinical Outcomes – case reviews
T. Spalding, Coventry/UK
10.1.3 TRUFIT CB Plug: 4-year MRI Evaluations – What transpires over time
M. Dhillon, Coventry/UK
Session 10.2 Geistlich Satellite Symposium
Is it worth repairing cartilage in the Talus?
12:45 PM - 01:45 PM
Room: Tramuntana 2 & 3
Moderators: Victor Valderrabano (CH)
10.2.1 Mesenchymal stem cells and in-situ cartilage regeneration
W. Richter, Heidelberg/DE
10.2.2 Cartilage Repair Strategies in the ankle joint
C. Becher,
10.2.3 Osteochondral lesions of the Talus: Diagnosis and Treatment
V. Valderrabano, Basel/CH
Session 10.3 Tigenix Satellite Symposium
The latest development in cartilage regeneration
12:45 PM - 01:45 PM
Room: Garbi
Moderators: Stefan Nehrer (AT)
10.3.1 New Material Technology form the labs of University of Cambridge and MIT
A. Lynn, L. Hangody, Cambridge/UK
10.3.2 New evidence from the 5 year clinical results of ChondroCelect versus Microfracture
D.B. Saris, Utrecht/NL
Session 10.4 Anika Satellite Symposium
Cartilage regeneration with Hyalograft® C autograft: Long term clinical results and future perspectives
12:45 PM - 01:45 PM
Room: Llevant 3,4 & 5
10.4.1 ACI 2010: An update on methodology and clinical results using Hyalograft C autograft transarthroscopically
M. Brittberg, Kungsbacka/SE
10.4.2 5-7 year clinical results with Hyalograft C. Proposed guidelines for patient selection and rehabilitation programs
E. Kon, Bologna/IT
10.4.3 How to improve cartilage repair. An overview of basic science studies with Hyalograft C autograft
S. Concaro, Göteborg/SE
3918 The informative role of the HYAFF® scaffold on genotypic redifferentiation of healthy and arthritic chondrocytes
A.P. Hollander, Bristol/UK
Session 11.1
Physical Stimulation of Cartilage Repair
02:00 PM - 03:00 PM
Room: Auditorium
Moderators: Stefano Della Villa (IT), Jan Schagemann (DE)
11.1.1 Physical stimulation of cartilage repair by pulsed electromagnetic fields
M. Cadossi, Bologna/IT
11.1.2 Mechanical stimulation to induce proteoglycans & collagen synthesis
D. Lee, London/UK
11.1.3 Mechanobiology
P. Prendergast, Dublin/IE
Session 11.2
Proteomics & Genomics
02:00 PM - 03:00 PM
Room: Garbi
Moderators: Anthony Hollander (UK), Linda Sandell (US)
11.2.1 New insights into cartilage biology and pathology using mouse cartilage proteomics
J.F. Bateman, R. Wilson, S. Zivkovic, Melbourne/AU
11.2.2 Pre-clinical applications of proteomics & genomics
L.A. Fortier, Ithaca, NY/US
11.2.3 Specific regions of genome contribute to articular cartilage regeneration and osteoarthritis resistance in mice
M.F. Rai, S. Hashimoto, J. Cheverud, L.J. Sandell, St. Louis/US
Session 11.3
Distraction Arthroplasty
02:00 PM - 03:00 PM
Room: Tramuntana 2 & 3
Moderators: Roland Jakob (CH), Francesco Iacono (IT)
11.3.1 Cartilage repair by joint distraction in experimental models of joint degeneration
T. Ishii, Tsukuba/JP
11.3.2 Clinical application of joint distraction in treatment of end-stage knee osteoarthritis; induction of cartilage repair
F.P.J.G. Lafeber, Utrecht/NL
11.3.3 Challenge of Repairing Large Cartilage Defects with Minimally Invasive Technique
M. Ochi, Hiroshima/JP
Session 12.1 Free Papers
Proteomics, Genomics & Biomarkers
03:00 PM - 04:30 PM
Room: Llevant 3,4 & 5
Moderators: Bruce Caterson (UK), Wayne McIlwraith (US)
12.1.1 Overview and Introduction
W. McIlwraith, Fort Collins, CO/US
12.1.2 The small heat-shock protein HSP27, shows a decreased abundance in OA and mediates IL-1b induced IL-6 secretion in human articular chondrocytes
S. Lambrecht, K.F. Almqvist, P.C. Verdonk, G. Verbruggen, D. Deforce, D. Elewaut, Gent/BE
12.1.3 Effect of IL-1β on the proteome of chondrocytes derived from human osteoarthritic cartilage- a pharmacoproteomics approach for drug screening
H. Zwickl1, E. Niculescu-Morzsa1, V. Haudek2, C. Gerner2, F. Halbwirth1, M. Berger1, S. Nehrer1, 1Krems/AT, 2Vienna/AT
12.1.4 Phenotypic differences between in vitro expanded articular chondrocytes and mesenchymal stem cells: a proteomic study.
M. Polacek, I. Martinez, Tromsø/NO
12.1.5 The effect of cellular passage, quantity and in vitro 3-D matrix culturing time on gene expression profiles before and after matrix-assisted chondrocyte transplantation (MACT) in a leporine animal model
G.M. Salzmann1, M. Sauerschnig2, M. Berninger2, T. Sütfels2, M. Schönfelder2, P.B. Schöttle2, A.B. Imhoff3, 1Freiburg/DE, 2Munich/DE, 3München/DE
12.1.6 Grem1, FRZb and DKK1 are highly specific markers for articular cartilage which prevent hypertrophic differentiation
J. Leijten1, J. Emons2, C. Sticht3, E. Dekker4, G. Rappold4, J.M. Wit2, C. Van Blitterswijk1, M. Karperien1, 1Enschede/NL, 2Leiden/NL, 3Heidelberg/DE, 4Mannheim/DE
12.1.7 Intraarticular platelet rich plasma ( PRP) therapy evaluated in 42 sport horses with Osteoarthrosis (OA)
M. Prades, I. Abellanet, Barcelona/ES
12.1.8 Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review
J.M. Hoch, C.G. Mattacola, J.S. Howard, C. Lattermann, Lexington, KY/US
12.1.9 Synovial fluid changes related to pathology
R. Esparza, J. Moya-Angeler, P. Martinez de Albornoz, R. Sanchez Hidalgo, I. Zapero, F. Forriol Campos, Majadahonda/ES
Session 12.2 Free Papers
Rehabilitation & Outcome
03:00 PM - 04:30 PM
Room: Garbi
Moderators: Mario Bizzini (CH), Karen Hambly (UK)
12.2.1 Overview and Introduction
K. Hambly, Chatham/UK
12.2.2 Two-year clinical and radiological evaluation following a prospective, randomized comparison of traditional and accelerated approaches to post-operative rehabilitation following matrix-induced autologous chondrocyte implantation
J. Ebert1, M. Fallon2, W.B. Robertson1, D.G. Lloyd1, T.R. Ackland1, M.H. Zheng2, D.J. Wood2, 1Perth, WA/AU, 2Perth/AU
12.2.3 Comparison of knee strength pre-operatively, and at 6 and 12 months post-operatively following autologous chondrocyte implantation(ACI)
C.G. Mattacola, J.S. Howard, J.M. Hoch, C. Lattermann, Lexington, KY/US
12.2.4 High patient compliance to an identical rehabilitation guideline after characterized chondrocyte implantation or microfracture is related to improved patient functional outcome at 2 years
D. Van Assche1, D. Van Caspel2, F. Staes1, D.B. Saris2, J. Bellemans1, J. Vanlauwe1, F. Luyten1, 1Leuven/BE, 2Utrecht/NL
12.2.5 Changes in functional performance during walking, squatting, rising, and stepping following autologous chondrocyte implantation (ACI)
J.S. Howard, C.G. Mattacola, J.M. Hoch, C. Lattermann, Lexington, KY/US
12.2.6 ACI vs Mosaicplasty for Symptomatic Articular Cartilage Lesions in the Young Adult Knee. Ten-year Results of Randomized Comparison Study
G. Bentley1, L.C. Biant2, S. Vijayan1, S. MacMull1, 1Stanmore/UK, 2Edinburgh/UK
12.2.7 Prospective Evaluation of Meniscal Transplantation Procedure: Minimum 7-year Follow-Up
E. Daley1, S. Bajaj1, J. Kercher2, E. Strauss1, P.B. Lewis1, B.J. Cole1, 1Chicago, IL/US, 2Chicago/US
12.2.8 Indication of articular cartilage formation inside Trufit® plugs one year after implantation as analyzed by delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC)
J.E.J. Bekkers, L.B. Creemers, W.J.A. Dhert, D.B. Saris, Utrecht/NL
12.2.9 Chondroprotective effects of a polycarbonate-urethane meniscal implant in a sheep model
G. Zur1, J.J. Elsner1, E. Linder-Ganz1, J. Shani1, O. Brenner1, E. Hershman2, F. Guilak3, A. Shterling1, 1Netanya/IL, 2New York, NY/US, 3Durham, NC/US
Session 12.3 Free Papers
Biomaterials & Scaffolds
03:00 PM - 04:30 PM
Room: Tramuntana 2 & 3
Moderators: Jennifer Elisseeff (US), Stefan Nehrer (AT)
12.3.1 Overview and Introduction
J. Elisseeff, Baltimore, MD/US
12.3.2 Development of a Flexible Tissue Engineered Ear
M.A. Randolph1, C.A. Sundback2, I. Pomerantseva2, D.A. Bichara1, X. Zhao2, K.M. Kulig2, L. Zhou2, E. Bassett2, N. Hwang3, R. Langer3, D.G. Anderson3, M. Cheney2, T. Hadlock2, J. Vacanti2, 1Boston, MA/US, 2Boston/US, 3Cambridge/US
12.3.3 MR evaluation of repair tissue in osteochondral defects following treatment with acellular scaffolds: high resolution MR-histological correlation in a goat model
C.S. Winalski, M.F. Freire, F.A. Sakamoto, E. Schneider, R. Midura, A. Vasanji, Cleveland, OH/US
12.3.4 Liposomes-enriched fibrin scaffold in cartilage regeneration.
E. Filova1, M. Rampichová1, A. Lytvynets1, A. Míčková1, J. Uhlík1, L. Vajner1, L. Martinova2, E. Prosecká1, D. Usvald3, J. Motlík3, E. Amler1, 1Prague/CZ, 2Liberec/CZ, 3Liběchov/CZ
12.3.5 One stage osteochondral repair with cartilage fragments in a hyaluronic acid/fibrin glue/platelet rich plasma scaffold: in vitro human and in vivo rabbit and goat animal model
A. Marmotti1, F. Castoldi1, R. Rossi1, C. Realmuto1, M. Bruzzone1, D.E. Bonasia1, U. Cottino1, B. Peyrone2, M. Mauthe von Degerfeld2, P. Rossi1, 1Torino/IT, 2Grugliasco/IT
12.3.6 Giant cell foreign body reactions to osteobiologic implants: case reports
S.K. Tabet, Albuquerque, NM/US
12.3.7 Use of a biphasic copolymer scaffold for the treatment of isolated osteochondral defects of the femoral condyle
F.A. Petrigliano1, H. Su2, I. Solsky1, L.F. Foo2, S. Rodeo2, T.L. Wickiewicz1, R.F. Warren2, H.G. Potter2, R.J. Williams, III1, 1New York/US, 2New York, NY/US
12.3.8 Nano-composite biomaterial used as salvage procedure for the treatment of massive osteochondral lesions.
M. Delcogliano, D. Marotta, F. Pezzillo, C.F. De Biase, R. Giacomi, M. Manili, A. Delcogliano, Roma/IT
12.3.9 Repair tissue assessment after matrix associated autologous chondrocyte transplantation with CaReS in the knee – Quantitative MRI evaluation at 3.0 Tesla
D. Stelzeneder1, S. Domayer1, S. Nehrer2, T. Luksch2, R. Dorotka1, S. Goed1, T.C. Mamisch3, G.H. Welsch1, S. Trattnig1, 1Vienna/AT, 2Krems/AT, 3Berne/CH
Session 12.4 Free Papers
Clinical Outcome 1
03:00 PM - 04:30 PM
Room: Auditorium
Moderators: Peter Behrens (DE), Deepak Goyal (IN)
12.4.1 Overview and Introduction
D. Goyal, Ahmedabad/IN
12.4.2 Characterized Chondrocyte Implantation versus microfracture for the treatment of symptomatic cartilage defects in the knee in patients with short onset of symptoms, 60 month follow-up
J. Vanlauwe1, D.B. Saris2, J. Victor3, K.F. Almqvist4, J. Bellemans1, R. Verdonk4, F.P. Luyten1, 1Leuven/BE, 2Utrecht/NL, 3Assebroek/BE, 4Gent/BE
12.4.3 The full arthroscopic technique of autologous chondrocyte transplantation using chondrospheres - safety study with 2 years follow up
S. Roessing1, T. Schreyer2, P. Baum3, H. Thermann4, H. paessler4, 1Mannheim/DE, 2Darmstadt/DE, 3Gundelfingen/DE, 4Heidelberg/DE
12.4.4 Effect of gender in the follow-up after matrix-associated autologous chondrocyte transplantation (MACT) as assessed by morphological and biochemical magnetic resonance imaging
G.H. Welsch1, S. Werner1, D. Stelzeneder1, T.C. Mamisch2, F. Hennig3, S. Domayer1, L. Zak1, S. Marlovits1, A. Kautzky-Willer1, S. Trattnig1, 1Vienna/AT, 2Berne/CH, 3Erlangen/DE
12.4.5 Time-line for self-reported changes in function following autologous chondrocyte implantation (ACI) over one year
C. Lattermann, J.S. Howard, J.M. Hoch, C.G. Mattacola, Lexington, KY/US
12.4.6 What is the impact of untreated severe cartilage damage on clinical outcomes and osteoarthritis progression in the knee? A natural history study.
W. Widuchowski, G. Kwiatkowski, R. Faltus, A. Mroczka, J. Widuchowski, Piekary Śląskie/PL
12.4.7 Correlation of tissue histomorphometry with ICRS histology scores in biopsies obtained from a randomized controlled clinical trial comparing BST-CarGel™ versus microfracture
C.D. Hoemann1, N. Tran-Khanh1, S. Methot2, G. Chen1, C. Marchand1, V. Lascau-Coman1, E. Rossomacha2, C. Jarry2, A. Restrepo2, W.D. Stanish3, P. MacDonald4, N. Mohtadi5, P. Marks6, M. Malo1, R. McCormack7, J. Desnoyers8, S. Pelet9, F. Lopez-Olivia10, J. Vaquero10, F. Macule11, M.S. Shive2, M.D. Buschmann1, 1Montreal, QC/CA, 2Laval, QC/CA, 3Halifax, NS/CA, 4Winnipeg, MB/CA, 5Calgary, AB/CA, 6Toronto, ON/CA, 7Vancouver, BC/CA, 8Greenfield Park, QC/CA, 9Quebec City, QC/CA, 10Madrid/ES, 11Barcelona/ES
12.4.8 BST-CarGel™ treatment shows trend of improved collagen architecture and stratified hyaline structure compared to microfracture in 13 month biopsies from an interim analysis of a randomized controlled clinical trial
A. Changoor1, M. Nelea1, N. Tran-Khanh1, S. Methot2, A. Restrepo2, W.D. Stanish3, P. MacDonald4, N. Mohtadi5, P. Marks6, M. Malo1, R. McCormack7, J. Desnoyers8, S. Pelet9, F. Lopez-Olivia10, J. Vaquero10, F. Macule11, M. Shive2, M.D. Buschmann1, 1Montreal/CA, 2Laval/CA, 3Halifax/CA, 4Winnipeg, MB/CA, 5Calgary/CA, 6Toronto/CA, 7Vancouver, BC/CA, 8Greenfield Park, QC/CA, 9Quebec City, QC/CA, 10Madrid/ES, 11Barcelona/ES
12.4.9 Comparison of the size of the cartilage femoral condyle lesions in CARTIPATCH® phase III clinical trial versus mosaicplasty
F. Dubrana1, J.-F. Potel2, C. Bussiere3, E. Servien4, H. Robert5, E. Stindel1, 1Brest/FR, 2Toulouse/FR, 3Dracy Le Fort/FR, 4Lyon/FR, 5Mayenne/FR
Session 13.0 Plenary
General Assembly / Business Meeting (For Members only)
04:30 PM - 05:45 PM
Room: Tramuntana 2 & 3
Posterviewing Cocktail / Exhibition
05:00 PM - 06:30 PM
Room: Technical Exhibition
Monday, Sept 27