Tuesday, September 28, 2010
Session 14.1 Instructional Course (Pre-registration required)
How to read an MRI for cartilage defects
07:30 AM - 08:15 AM
Room: Llevant 3,4 & 5
Instructor: Stefan Marlovits (AT)
Session 14.2 Instructional Course (Pre-registration required)
How to set-up an animal models study
07:30 AM - 08:15 AM
Room: Tramuntana 2 & 3
Instructor: Wayne McIlwraith (US)
Session 14.3 Workshop
Meet the Experts for clinicians
07:30 AM - 08:15 AM
Room: Garbi
Moderators: Rene Verdonk (BE), Pedro Guillen (ES)
Session 15.0 Plenary
Biomaterials
08:30 AM - 09:30 AM
Room: Auditorium
Moderators: Mats Brittberg (SE), Ilkka Kiviranta (FI)
15.0.1 The ideal biomaterial for cartilage repair - a biological approach
M.D. Buschmann, Montreal/CA
15.0.2 The ideal biomaterial for cartilage repair - a clinical approach
C. Erggelet, Zurich/CH
15.0.3 Clinical results with the use of biomaterials for cartilage repair
S. Nehrer, F. Halbwirth, Krems/AT
Session 16.1
Biologic Arthroplasty
09:30 AM - 10:30 AM
Room: Tramuntana 2 & 3
Moderators: Daniel Saris (NL), José Romero (CH)
16.1.1 Biologic Unicompartmental Knee Replacement
J. Farr, Indianapolis, IN/US
16.1.2 Treatment of early osteoarthritis with cartilage regeneration techniques
A.W. Gobbi, Milano/IT
16.1.3 Where is the line between cartilage regeneration and biologic arthroplasty?
C.D. Hoemann, Montreal, QC/CA
Session 16.2
Development of new Biomaterials & Scaffolds
09:30 AM - 10:30 AM
Room: Auditorium
Moderators: Alberto Gobbi (IT), Alan Nixon (US)
16.2.1 Growth factor-delivering scaffolds for cartilage tissue engineering
C. Brochhausen1, R. Zehbe2, B. Watzer3, C.J. Kirkpatrick1, 1Mainz/DE, 2Berlin/DE, 3Marburg/DE
16.2.2 Functionalisation of biomaterials to improve cartilage repair
J. Elisseeff, Baltimore, MD/US
16.2.3 Towards cartilage grafts with zonal organization
J. Malda, W. Schuurman, P.R. van Weeren, W.J.A. Dhert, Utrecht/NL
Session 16.3
TE/TR in other Musculoskeletal Tissues
09:30 AM - 10:30 AM
Room: Garbi
Moderators: Pedro Guillen (ES), Mark Randolph (US)
16.3.1 Cartilage Repair and Degradation: A Balance at the Molecular, Cell, and Tissue Levels
A. Grodzinsky, Cambridge/US
16.3.2 What can we learn from regenerative approaches for IVD?
R. Kandel, Toronto/CA
16.3.3 What can we learn from regenerative approaches for tendons?"
R. Smith, Herts/UK
Coffee Break
10:30 AM - 11:00 AM
Room: Technical Exhibition
Session 17.1 Free Papers
Clinical Outcome II
11:00 AM - 12:30 PM
Room: Tramuntana 2 & 3
Moderators: Jorge Fabian Urraza (ES), Tom Minas (US)
17.1.1 Overview and Introduction
T. Minas, Chestnut Hill/US
17.1.2 ICRS histology scores of biopsies from an interim analysis of a randomized controlled clinical trial show significant improvement in tissue quality at 13 months for BST-CarGel™ versus microfracture
S. Méthot1, C.D. Hoemann2, E. Rossomacha1, A. Restrepo1, W.D. Stanish3, P. MacDonald4, N. Mohtadi5, P. Marks6, M. Malo2, R. McCormack7, J. Desnoyers8, S. Pelet9, F. Lopez-Olivia10, J. Vaquero10, F. Macule11, M.S. Shive1, M.D. Buschmann2, 1Laval/CA, 2Montreal/CA, 3Halifax/CA, 4Winnipeg, MB/CA, 5Calgary/CA, 6Toronto/CA, 7Vancouver, BC/CA, 8Greenfield Park, QC/CA, 9Quebec City, QC/CA, 10Madrid/ES, 11Barcelona/ES
17.1.3 Mid-term results of Autologous Matrix Induced Chondrogenesis (AMIC) for treatment of focal cartilage defects in the knee
J. Gille1, J. Wimmer2, E. Schuseil1, J. Gellissen3, S. Wallstabe3, P. Behrens3, 1Lübeck/DE, 2Luebeck/DE, 3Hamburg/DE
17.1.4 TruFit plugs for cartilage repair in the knee. 4 year results and refining the indications
T. Spalding, P. Thompson, M. Dhillon, J. Bird, Coventry/UK
17.1.5 New nanostructured biomimetic scaffold for the treatment of ostechondral defects: pilot clinical study at 3 years follow-up
E. Kon, G. Filardo, A. Di Martino, S. Patella, S. Zaffagnini, L. D'Orazio, G. Altadonna, M. Marcacci, Bologna/IT
17.1.6 Influence of the cell differentiation at the timepoint of transplantation on the clinical outcome of matrix-associated chondrocyte transplantation (MACT)
C. Albrecht, L. Zak, B. Tichy, S. Hosiner, V. Vecsei, S. Marlovits, Vienna/AT
17.1.7 Prospective Evaluation of Autologous Chondrocyte Implantation Procedure: Minimum 7-year Follow-Up
E. Daley1, S. Bajaj1, J. Kercher2, M. Salata2, B.J. Cole1, 1Chicago, IL/US, 2Chicago/US
17.1.8 Articular cartilage repair using collagen type I hydrogels (CaReS-technology)– Results of a multicenter study
U. Nöth, Würzburg/DE
17.1.9 Comparison in clinical outcome of first generation ACT with ACT of third generation with spheroids
T. Schreyer, Darmstadt/DE
Session 17.2 Free Papers
Cartilage Defects & Instability
11:00 AM - 12:30 PM
Room: Garbi
Moderators: Mats Brittberg (SE), Rodrigo Mardones (CL)
17.2.1 Overview and Introduction
R.M. Mardones, Santiago/CL
17.2.2 Autologous Chondrocyte Implantation for Cartilage Lesions with Malalignment of the Patellofemoral Joint -Long Term Results
H.S. Vasiliadis1, M. Brittberg2, A. Lindahl1, L. Peterson1, 1Gothenburg/SE, 2Kungsbacka/SE
17.2.3 Cartilage load before and after opening-wedge high tibial osteotomy
M. Lind1, J. Mcclelland2, K. Webster2, J. Wittwer2, T. Whitehead3, J. Feller2, 1Aarhus/DK, 2Bundoora, VIC/AU, 3Richmond, VIC/AU
17.2.4 Patella cartilage – relationship between T2 mapping and measurements of patello-femoral joint alignment
G. Scheurecker1, M. Vlychou2, S. Apprich1, D. Stelzeneder1, A. Messner1, G.H. Welsch1, S. Trattnig1, 1Vienna/AT, 2Larissa/GR
17.2.5 Psychometric evaluation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales for patients with articular cartilage lesions of the knee using pilot study data of the Cartilage Autograft Implantation System (CAIS)
L. Nelson1, L.D. McLeod1, M.M. Mordin1, J. Farr2, B.J. Cole3, S. Uddin4, L. Engelhart5, 1Research Triangle Park, NC/US, 2Indianapolis, IN/US, 3Chicago, IL/US, 4Raynham, MA/US, 5Milford, NJ/US
17.2.6 Improved life quality in patients with hip Osteoarthritis treated with an implant of cartilage artifical matrix
E. Hermida, L.F. Hermida, Mexico City/MX
17.2.7 Preliminary result of repairing articular cartilage defect by autogenous chondrocyte implantation: the feasibility study of a novel biphasic osteochondral composite
H. Chiang1, C.-C. Jiang1, C.-J. Liao2, C.-Y. Shen1, C.-S. Shieh1, Y.-Y. Huang1, 1Taipei/TW, 2Hsinchu/TW
17.2.8 Treatment of osteochondritis dissecans of the knee by arthroscopic one-step repair technique with bone marrow-derived cells
M. Cavallo, F. Vannini, R. Buda, A. Ruffilli, R. Ghermandi, C. Cavallo, B. Grigolo, S. Giannini, Bologna/IT
17.2.9 Effect of hyperbaric oxygen and compression on chondrocyte proliferation
B. Sievers1, N. Hoechsmann1, F. Dueren2, C. Melcher1, S. Mayer1, P.E. Müller1, 1München/DE, 2Bernau-Felden/DE
Session 17.3 Free Papers
Other Musculoskeletal Tissues
11:00 AM - 12:30 PM
Room: Llevant 3,4 & 5
Moderators: Simon Görtz (US), José Couceiro (ES)
17.3.1 Overview and Introduction
S. Görtz, San Diego, CA/US
17.3.4 The suture of menisceal tears in the avascular zone enforced by a collagen I/III membrane: Clinical experience over 6 years and animal experiments
R. Jakob1, M. Jacobi1, D. Nesic2, P. Mainil-Varlet2, 1Fribourg/CH, 2Bern/CH
17.3.2 Human cultured fibroblasts isolated from anterior cruciate ligament have different growth rates depending on the age of the patient and the type of lesion
P. Guillen, E. Rodriguez-Iñigo, I. Guillen-Vicente, R. Caballero-Santos, M. Guillen-Vicente, E. Santos, F. Garcia-Gomez, T. Fernandez-Jaen, J.M. Lopez-Alcorocho, Madrid/ES
17.3.3 Long-term clinical and radiological follow-up of viable meniscal allografts.
P.C. Verdonk1, J. van der Maas2, T. Tampere2, K.F. Almqvist1, R. Verdonk1, 1Gent/BE, 2Ghent/BE
17.3.5 TKAMen: A new source for meniscus reconstruction
T. Brune, C. Martin, L. Barnouin, Mions/FR
17.3.6 Lateral Collagen Meniscus Implant (Menaflex): Prospective European Multicenter Study with 2 Year Minimum Follow-Up
J.C. Monllau1, R. Crespo2, S. Zaffagnini3, M. Marcacci3, R. Berbig4, D.G. Holsten5, P. Bulgheroni6, K. Lagae7, 1Barcelona/ES, 2Alcazar De San Juan/ES, 3Bologna/IT, 4Zürich/CH, 5Koblenz/DE, 6Varese/IT, 7Antwerp/BE
17.3.7 Feasibility study of adapting the delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique for the meniscus
J.E.J. Bekkers1, B. Claassen1, L.B. Creemers1, W.J.A. Dhert1, A.P. Hollander2, D.B. Saris1, 1Utrecht/NL, 2Bristol/UK
17.3.8 New process for the production of an acellular meniscus scaffold
T. Brune, A. Schirlin, C. Martin, L. Barnouin, Mions/FR
17.3.9 An Ex Vivo Organ Culturing and Loading System for Large Species Intervertebral Discs; a Feasibily Study With Caprine Lumbar Discs.
C.P.L. Paul, H.A. Zuiderbaan, B. Zandieh Doulabi, A.J. Veen van der, T.H. Smit, M. Helder, B.J. Royen van, M.G. Mullender, Amsterdam/NL
Session 17.4 Free Papers
Osteoarthritis
11:00 AM - 12:30 PM
Room: Auditorium
Moderators: Sally Roberts (UK), Matthias Steinwachs (CH)
17.4.1 Overview and Introduction
M. Steinwachs, Zürich/CH
17.4.2 Local anesthetics exposure leads to mitochondrial oxidative stress and oxidative damage in human chondrocytes.
V. Grishko1, A.W. Pearsall, IV2, G.L. Wilson2, 136688/US, 2Mobile, AL/US
17.4.3 Matrilin-1 and matrilin-4: new disease causing loci for multiple epiphyseal dysplasia?
M.-M. Ristiluoma1, A. Aszodi2, 1Oulu/FI, 2Martinsried/DE
17.4.4 Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis
P.-J. Francin1, S. Pallu2, C. Guillaume1, P. Pottie1, D. Mainard3, N. Presle1, 1Vandoeuvre Les Nancy/FR, 2Orleans/FR, 3Nancy/FR
17.4.6 Treatment with chondroitin sulfate reduces cartilage volume loss in knee oa patients assessed by MRI: a randomized, double-blind, placebo controlled pilot study
J.P. Pelletier1, L.M. Wildi1, J.P. Raynauld1, A.D. Beaulieu2, L. Bessette3, F. Morin4, M. Dorais5, J. Martel-Pelletier1, 1Montreal/CA, 2Quebec/CA, 3Sainte-Foy/CA, 4Trois-Rivières/CA, 5Notre-Dame De l'Ïlle-Perrot/CA
17.4.7 Osteoarthritis after intense sports activity
M.I. Iosifidis, D. Neophytou, T. Liakos, I. Melas, K. Apostolidis, T. Kyriakidis, A. Kyriakidis, Thessaloniki/GR
17.4.8 12 year follow-up of ACL Reconstruction: Long Term Outcomes of Prospectively Studied Osseous and Articular Injuries
B.T. Hanypsiak1, K. Spindler2, R. Parker3, G. Calabrese3, B. Richmond3, C. Rothrock4, T. Herrenbruck5, 1East Setauket, NY/US, 2Nashville, TN/US, 3Cleveland, OH/US, 4St. Louis, MO/US, 5Salina, KS/US
17.4.5 Autologous Matrix-Induced Chondrogenesis (AMIC) on the patella plus periosteal coverage on the trochlea combined with mechanical realignment- A New Treatment Option in Symptomatic Isolated Femoropatellar Osteoarthritis due to Subluxation of the Patella
T. Kusano1, C. Marti2, M. Jacobi2, R. Jakob2, 1Tafers/CH, 2Fribourg/CH
17.4.9 Type II collagen fragment HELIX-II is a marker of early cartilage damage but is insensitive to predict progression of cartilage destruction in human knee joint synovial fluid
X. Wei1, K. Li1, L. Wei2, 1Taiyuan/CN, 2Providence/US
Individual industrial - ICRS Board Meetings (upon invitation only)
11:00 AM - 12:30 PM
Room: Mestral 4
Session 18.1 Genzyme Satellite Symposium
Setting New Standards in the Field of Articular Cartilage Repair: Trial Design, Outcome Assessments and Minimally Invasive Surgical Techniques
12:45 PM - 01:45 PM
Room: Auditorium
Moderators: Daniel Saris (NL)
18.1.1 MRI and Five-Year Clinical Results Following Treatment for Full Thickness Defects in the Knee with the MACI® Implant
D.B. Saris, Utrecht/NL
18.1.2 Innovative Technique and 2-Year Results Following Treatment with MACI® Implant for Full Thickness Defects in the Talar Dome
E. Giza, Davis/US
18.1.3 International Expert Recommendations for Arthroscopic Delivery of the MACI® Implant in the Knee
A. Gigante, Ancona/IT
Session 18.2 Orteq Satellite Symposium
Actifit®,an acellular synthetic meniscal substitute: Final 2 year results and early European clinical experience
12:45 PM - 01:45 PM
Room: Tramuntana 2 & 3
Moderators: Rene Verdonk (BE), Tim Spalding (UK)
18.2.1 Actifit® , Final 2 yr clinical results. MRI, Histology and Clinical outcome scores following implantation of a novel acellular meniscal scaffold for the treatment of irreparable partial meniscus tears and/or partial meniscal tissue loss.
R. Verdonk, P.C. Verdonk, Gent/BE
18.2.2 Joint preservation by realignment of the knee axis in combination with meniscal substitution procedures. ( iBalance Axial Knee Alignment System + Actifit® Meniscal Implant )
K.P. Slynarski, Warsaw/PL
18.2.3 My experience of Meniscal substitutes : Menaflex and Actifit®
T. Spalding, Coventry/UK
18.2.4 Actifit® : My Actifit® case series – a 25 subject follow-up
H. Laprell, Kiel/DE
18.2.5 The use of a Biomimetic scaffold and a meniscal substitute. Early results for the combined treatment of osteochondral lesions and irreparable meniscal tears
E. Kon, Bologna/IT
Session 18.3 Arthrex Satellite Symposium
12:45 PM - 01:15 PM
Room: Garbi
18.3.1 Cartilage Repair Implant (Basic Science/Animal Studies).
L.A. Fortier, Ithaca, NY/US
18.3.2 Clinical application of the Cartilage Repair Implant
P.A. Davidson, Pinellas Park/US
Session 18.4 DJO Series of “Clinical Guidelines in Orthopaedics"
Decision making in Cartilage Repair
12:45 PM - 01:45 PM
Room: Llevant 3,4 & 5
Moderators: Mats Brittberg (SE), Claudio Zorzi (IT)
18.4.1 Which lesions should be treated and why?
M. Brittberg, Kungsbacka/SE
18.4.2 How to treat small cartilage lesions in patients with different ages (< 2cm2)
A.W. Gobbi, Milano/IT
18.4.3 How to treat medium-size (2-4 cm2) cartilage lesions in patients with different ages
E. Kon, Bologna/IT
18.4.4 How to treat large (>4cm2) cartilage lesions in patients with different ages
H. Madry, Homburg/DE
18.4.5 How to handle ligament instabilities and concomitant cartilage lesions?
S. Vogt, Munich/DE
Session 18.5 Universal Research Solutions Satellite Symposium: OBERD®
Linking Outcome-Based Research to Clinical Practice
01:15 PM - 01:45 PM
Room: Garbi
18.5.1 Clinical Research Comes Out of the [Computing] Cloud
O. Plummer, Columbia/US
18.5.2 Clinical Research Comes Out of the [Computing] Cloud 2
A. Hussam, Columbia/US
Session 19.0 Plenary
Biomechanics & Stability of Cartilage Repair
02:00 PM - 03:00 PM
Room: Auditorium
Moderators: Erhan Basad (DE), Damian Griffin (UK)
19.0.1 What do we know about the biomechanical properties of human cartilage repair tissue?
I. Kiviranta, Helsinki/FI
19.0.2 Does cartilage have to be perfect for a good clinical outcome?
E. Kon, G. Filardo, A. Di Martino, S. Patella, L. D'Orazio, B. Di Matteo, M. Marcacci, Bologna/IT
19.0.3 What do we know about the biomechanical properties of joint cartilage?
R.L. Sah, La Jolla, CA/US
Industry Liaison & Regulatory Committee Meeting
02:00 PM - 03:00 PM
Room: Mestral 4
Session 19.1
YSOS (Young Scientists and Orthopedic Surgeons)
03:00 PM - 04:00 PM
Room: Garbi
Moderators: Elizaveta Kon (IT), Peter Verdonk (BE)
19.1.1 The patello-femoral joint: What have we been doing so far?
M. Drobnič, Ljubljana/SI
19.1.2 Osteochondritis Dissecans in the Knee: Therapeutic Options
S. Görtz, San Diego, CA/US
19.1.3 The treatment of chondral lesion: a consensus algorithm
M. Jelic, Zagreb/HR
Session 19.3
Culture Techniques for controlling cell differentiation
03:00 PM - 04:00 PM
Room: Llevant 3,4 & 5
Moderators: Gerjo Van Osch (NL), Caroline Hoemann (CA)
19.3.1 Chondrogenic Commitment of Mesenchymal Stem Cells
F. Barry, Galway/IE
19.3.2 What are the culture medium requirements to maintain chondrogenic potential during expansion?
B. Johnstone, Portland/US
19.3.3 A 3D-culture model for the streamlined engineering of large-scale human cartilage grafts
I. Martin, B. Tonnarelli, R. Santoro, A. Barbero, D. Wendt, Basel/CH
Session 19.2 Spanish Roundtable
Reparation / Tisular Regeneration (in Spanish Language)
03:00 PM - 04:00 PM
Room: Tramuntana 2 & 3
Moderators: Jorge Fabian Urraza (ES), Angels Salvador Verges (ES)
19.2.1 Supervivencia ICAs mínimo 10 años. Nuevas tendencias
J. Couceiro, Santiago De Compostela/ES
19.2.2 Posibilidades terapéuticas del Plasma Rico en Factores de Crecimiento en las lesiones condrales.
M. Sanchez, Vitoria/ES
19.2.3 Instant Cemtrocell: un paso adelante en la reparación del cartílago articular mediante el implante de condrocitos antólogos
J.M. Lopez-Alcorocho, Madrid/ES
19.2.4 Meniscus response to growth factors in the vascular and avascular areas. Study in vitro
F. Forriol Campos, Madrid/ES
19.2.5 Amniotic membrane in cartilage repair
J. Vaquero, Madrid/ES
Session 20.1
ICRS Meets Spain
04:00 PM - 05:00 PM
Room: Tramuntana 2 & 3
Moderators: Ramon Cugat (ES), Pedro Guillen (ES)
20.1.1 From ACI to MACI to instant Cemtrocell
S.P. Abelow1, P. Guillen2, M. Guillen-Vicente2, I. Guillen-Vicente2, 1South Lake Tahoe/US, 2Madrid/ES
20.1.2 Autologous Growth Factors. Biological Approach
E. Anitua, Vitoria/ES
20.1.3 Reconstruction of Anterior Cruciate Ligament with Autologous Fibroblasts or Mesenchymal Cells Seeded on a Type I/III Collagen Membrane
M. Guillen-Vicente, Madrid/ES
Session 20.2
Deformities / Axis Deviation
04:00 PM - 05:00 PM
Room: Auditorium
Moderators: Jack Farr (US), Roland Jakob (CH)
20.2.1 The Indications for Osteotomy with Cartilage Restoration Procedures
W. Gersoff, Denver/US
20.2.2 Clinical techniques for the correction malalignment about the Knee
T. Minas, Chestnut Hill/US
20.2.3 Preoperative radiographic evaluation of axis deformities around the knee
S. Spruijt, Woerden/NL
Session 20.3
Travelling Fellowship Session (sponsored by Stryker)
04:00 PM - 05:00 PM
Room: Garbi
Moderators: Lisa Fortier (US), David Lickorish (US)
20.3.1 The Surgeon Consultant - managing the corporate relationship and conflicts of interest
K.R. Zaslav, Richmond/US
20.3.2 Comprehensive outcome analyses in experimental cartilage repair studies
D.B. Saris, Utrecht/NL
Poster Viewing
05:00 PM - 06:00 PM
Spanish Fiesta & Flamenco Night (€ 85.00)
07:30 PM - 11:00 PM (Bus Departure 7.00 PM at the Hotel Melia and Sitges Center)
Tuesday, Sept. 28